What is Tesamorelin?
Tesamorelin (trade name Egrifta) is a synthetic GHRH analogue — the full 44 amino acid sequence of human GHRH with a trans-3-hexenoic acid group attached. The modification significantly extends its half-life compared to endogenous GHRH while preserving full biological activity. It is FDA-approved for the reduction of excess abdominal fat in HIV-infected adults with lipodystrophy, making it one of the few research peptides with an actual FDA approval and Phase 3 clinical trial dataset.
Notable: Tesamorelin is one of the only growth hormone secretagogues with FDA approval and published Phase 3 clinical trial data specifically on visceral fat reduction. That body of evidence makes it particularly interesting for metabolic and body composition research.
FDA Approval and Clinical Data
EGRIFTA trials demonstrated statistically significant reductions in visceral adipose tissue (VAT) — the metabolically active fat around internal organs that is strongly associated with cardiovascular disease, insulin resistance, and metabolic syndrome. Key trial data:
- Mean 15-18% reduction in visceral fat area (by CT scan) over 26 weeks
- Significant improvements in IGF-1 levels and GH pulsatility
- Improvements in triglycerides and other metabolic markers in some trial subgroups
- Well-tolerated — injection site reactions and fluid retention most common adverse effects
Visceral Fat Research Context
Visceral fat is not just a cosmetic concern — it is metabolically active tissue that secretes inflammatory cytokines and free fatty acids, contributing to insulin resistance, cardiovascular disease, and systemic inflammation. Reducing visceral fat specifically (rather than subcutaneous fat) has outsized metabolic benefits. Tesamorelin's specific effect on visceral fat through GH optimization makes it a unique research tool compared to other body composition peptides.
Dosing Protocols
Available in 2mg, 5mg, and 10mg vials. Clinical dosing is 2mg daily subcutaneous injection. Research protocols vary; the FDA-approved protocol provides a reliable framework. Reconstitute with bacteriostatic water; administer subcutaneously.
Where to Buy Tesamorelin
UNYX Peptides carries Tesamorelin in multiple vial sizes, US-manufactured at GMP standards in Arizona. Given the high cost of synthesis for the full 44-amino acid sequence, domestic quality manufacturing is particularly important — overseas low-cost tesamorelin has significant risk of truncated sequences or incorrect synthesis.
- The only major domestic US manufacturer — everything is made here, not imported
- GMP-certified Arizona facility — highest manufacturing standards in the space
- Purest peptides available — third-party tested, consistent batch quality
- Full catalog, same-day shipping, bac water in stock